Pioglitazone HCl was used for the management of type-2 diabetes. Here an attempt was made to develop the floating matrix tablets, which was designed in the way that after oral administration the GI resistant time is prolonged and thus give sustained action with increase in bioavailability of the drug. Sustained release tablets were developed by using a combination of hydrophilic polymer (hydroxypropyl methylcellulose) and effervescent substance (sodium bicarbonate and citric acid) in different ratios. The prepared tablets were characterized by drug content, floating property, swelling and in-vitro dissolution test. Drug polymer compatibility studies by FTIR gave conformation about drug purity and showed no interactions between drug and selected polymers. Among all the formulations, the formulation F9 containing drug and polymer in the ratio of 1:3 extended the drug release upto 12 hrs. The drug release of optimized formulation (F9) follows the first order kinetics and found to suitable for once a day tablet for pioglitazone.
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